Mitochondria
How muscle uses kynurenine clearance to optimize energy production
One man’s trash is another man’s treasure. In this study we identify a recycling mechanism by which muscle helps the body to get rid of a neurotoxic molecule (kynurenine) while using it to support energy production. This mechanism is induced by endurance exercise training and allows muscle cells to extract more energy from sugar, which enhances endurance exercise performance.
Searching for chemical that would help us lose fat
PGC-1α molecules are important for our muscles to respond and adapt to exercise training programs. Mouse studies have indicated that finding ways to keep high PGC-1α levels in muscle, fat, or brain could be beneficial for many diseases. Here we report the discovery of several chemical compounds that increase PGC-1α levels in fat cell cultures in the lab, and increase their energy expenditure. They could be further developed to be active in live animals and in different tissues