Oct 2020

Exploring the inherent and adaptive components of exercise capacity

Physical exercise is great for our health. So much so that low exercise capacity is in itself a predictor of premature mortality. However, not everybody gets the same benefits from exercise, and some of us have to work much harder to get there. In this study, we try to understand why and identify genes associated with inherent exercise capacity and response to endurance training.

Original title

Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats

Jun 2020

How muscle uses kynurenine clearance to optimize energy production

One man’s trash is another man’s treasure. In this study we identify a recycling mechanism by which muscle helps the body to get rid of a neurotoxic molecule (kynurenine) while using it to support energy production. This mechanism is induced by endurance exercise training and allows muscle cells to extract more energy from sugar, which enhances endurance exercise performance.

Original title

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

Helping everyone to get fitter with least effort

Progress
99%

Finish a marathon or eat all the delicious food while keeping a six-pack, I will be providing the means, not the judgement


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