Our research aims to understand why physical exercise is such a powerful tool in the prevention and treatment of so many diseases. These include diabetes and obesity, muscular and neuromuscular diseases, mental health and neurodegenerative disorders, and certain cancers. We want to detail, at the molecular level, the mechanisms that confer the prophylactic and therapeutic effects of exercise, so we can develop therapies based on them.
Different modalities of exercise have different beneficial effects on human health. For example, endurance/aerobic exercise can improve the way our bodies utilize food-derived nutrients, whereas resistant exercise (such as weight lifting) can increase muscle mass and strength. Exercise affects the whole body, and that’s why our projects focus on different tissues such as skeletal muscle, liver, adipose tissue, and brain (so far…). By identifying the molecules that mediate the effects of exercise on different organs we can begin to imagine new therapies to prevent and treat diabetes, obesity, age-related loss of muscle function, but also help patients with neurodegenerative diseases and cancer.
Identifying the molecular mediators of the beneficial effects of physical exercise, and developing as a novel generation of therapeutics.