To identify the molecules that mediate the many beneficial effects of physical exercise on human health

Sedentary lifestyles come at a high cost to our health and have been linked to the incidence of diseases such as diabetes, obesity, cardiovascular disease, neurodegenerative diseases (Alzheimer’s and Parkinson’s), mood disorders (e.g. depression), and even cancer.

Physical activity and muscle condition play a clear and important role in the prevention and treatment of these diseases. However, exercise programs are not always viable treatment options due to inherent disease characteristics such as muscle weakness, difficulty in movement, or, in particular, patient compliance.

By understanding the mechanisms through which our bodies adapt to exercise, we can learn valuable lessons that can be translated into future disease therapies.

 Metabolism

How do tissues such as muscle, liver, and fat produce, use, or store energy to function in health and during metabolic diseases?

 

Muscle mass & function

What are the pathways that maintain adequate muscle mass and strength, which are dysregulated in many diseases? 

 

Inter-organ communication

Identifying the molecular mediators of the beneficial effects of physical exercise, and developing as a novel generation of therapeutics.